Tsiprolet and metronidazole compatibility



Is it possible to use Metronidazole and Tsiprolet together? This question worries many patients who are prescribed such combination therapy. To answer, it is necessary to compare Metronidazole and Tsiprolet, their mechanism of action and medicinal properties.

Treatment of some infectious and inflammatory diseases is effective only with the complex use of drugs that have different mechanisms of action. Thanks to this, it becomes possible to cover a wider range of pathogens. These drugs are Metronidazole and Tsiprolet.

pharmachologic effect

The main active ingredient of Tsiprolet is ciprofloxacin, which is part of the group of fluoroquinolones. In the process of influencing the topoisomerase of harmful microorganisms, the drug suppresses their reproduction, which causes a decrease in the concentration of bacteria and their subsequent death.

The antibiotic is active against aerobic pathogens, including microbes that produce beta-lactamase.

Metronidazole is an antibacterial agent that exhibits active antimicrobial and antiprotozoal effects. By interacting with deoxyribonucleic acid (DNA) found in bacterial cells, Metronidazole blocks the production of their nucleic acids, which causes the death of harmful microbes.

Shows activity against a large number of anaerobic microorganisms and protozoa.

Ciprofloxacin and Metronidazole at the same time: possible or not, compatibility

Is it possible to use Metronidazole and Tsiprolet together?
This question worries many patients who are prescribed such combination therapy. To answer, it is necessary to compare Metronidazole and Tsiprolet, their mechanism of action and medicinal properties. Treatment of some infectious and inflammatory diseases is effective only with the complex use of drugs that have different mechanisms of action. Thanks to this, it becomes possible to cover a wider range of pathogens. These drugs are Metronidazole and Tsiprolet.

pharmachologic effect

The main active ingredient of Tsiprolet is ciprofloxacin, which is part of the group of fluoroquinolones. In the process of influencing the topoisomerase of harmful microorganisms, the drug suppresses their reproduction, which causes a decrease in the concentration of bacteria and their subsequent death.

The antibiotic is active against aerobic pathogens, including microbes that produce beta-lactamase.

Metronidazole is an antibacterial agent that exhibits active antimicrobial and antiprotozoal effects. By interacting with deoxyribonucleic acid (DNA) found in bacterial cells, Metronidazole blocks the production of their nucleic acids, which causes the death of harmful microbes.

Shows activity against a large number of anaerobic microorganisms and protozoa.

Efficacy of ciprofloxacin

The spectrum of antimicrobial activity of the drug is similar to other second-generation fluoroquinolones:

  • powerful bactericidal effect on gram-negative microorganisms;
  • due to low sensitivity, it is not advisable to prescribe for the treatment of diseases caused by pneumococci, enterococci, intracellular pathogens (chlamydia and mycoplasma);
  • absolute resistance to the second generation in spirochetes, listeria and most anaerobes.

Effectiveness against Gram+ flora is average. The exception is Bacillus anthracis. Ciprofloxacin ® is used to treat all forms of anthrax (pulmonary, cutaneous, intestinal, anthrax).

This disease is an acute, particularly dangerous, zoonotic infection. The vast majority of cases of the disease occur in the cutaneous form. This is explained by the fact that the clinical form is determined by the dose of the pathogen, the mechanism of infection and the state of immunity of the macroorganism.

Inhalational anthrax accounts for about five percent of all cases of infection. It is characterized by an extremely severe course and high mortality rates (up to 90% within three days).

Ciprofloxacin ® should be used intravenously and in mandatory combination with rifampicin ® , clindamycin ® , ampicillin ® , gentamicin ® or simultaneously with another antibiotic active against Bacillus anthracis.

Application

Quite often, doctors prescribe Metronidazole along with Tsiprolet. This is due to the fact that compatibility enhances the antimicrobial activity of drugs.

The following indications exist for the use of drugs in combination:

  • infectious and inflammatory processes in the gynecological area;
  • severe infections caused by anaerobic microorganisms;
  • infectious and inflammatory lesions of the peritoneum, severe, complicated by peritonitis.
  • infection with protozoa causing mixed abdominal infections.

Dosage and usage patterns

Combination therapy helps to increase the activity of the drugs used against a wide range of pathogens.

The combination of Tsiprolet with certain antimicrobial substances, for example, beta-lactam antibiotics, aminoglycoside drugs, as well as clindamycin and Metronidazole, significantly increases the effectiveness of the drug. That is why quite often doctors prescribe a treatment regimen in which it is necessary to take drugs at the same time.

For the treatment of infectious and inflammatory diseases, joint therapy with Metronidazole and Tsiprolet is prescribed.

For vaginal infections, it is possible to use suppositories or Metronidazole gel and Tsiprolet tablets.

Suppositories and gel are used intravaginally. Usually one suppository is prescribed per day (at night). The duration of the therapeutic course is 10 days. The standard dose of the gel is a full applicator or 5 g of active substance twice a day. The duration of treatment is 5 days.

If Metronidazole tablets are used, the standard dosage is as follows: 1 - 2 tablets (250 - 500 mg) should be taken 2 - 3 times a day. Duration of therapy is from 5 to 10 days.

Simultaneously with Metronidazole, it is necessary to drink Tsiprolet in the following dose: from 250 to 500 mg twice a day. The duration of the therapeutic course is from 7 to 10 days.

At the end of treatment, it is necessary to conduct an appropriate examination to ensure the effectiveness of the therapy used.

Found a mistake? Select it and press Ctrl + Enter

source: pillsman.org

The pharmaceutical medicine called ciprolet is an antimicrobial agent, and ciprolet is also an antibiotic.

Comparisons

In terms of pharmacokinetic parameters, Metronidazole is inferior to Ornidazole. The drug allows you to reduce the duration of therapy, while the therapeutic effect occurs much faster. The drug has better compliance and tolerability.

Therapeutic concentrations of Ornidazole in the blood remain long enough, which makes it possible to achieve complete elimination of urogenital trichomonas. Ornidazole does not interact with alcohol dehydrogenase in any way, so it is permissible to drink alcoholic beverages during the treatment period.

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Domestic medicine allows the use of the drug during pregnancy. Ornidazole has a longer half-life (13 hours), binding to blood proteins does not exceed 15%. The bioavailability of drugs is approximately the same, but for Ornidazole it is at least 90%. How Metronidazole can be replaced and whether Ornidazole is suitable for this is decided only by the supervising physician.

There is no significant difference between the drugs. Indications for use are almost completely the same.

However, Tinidazole enhances the effect of drugs that reduce the activity of the blood coagulation system and prevent excessive formation of blood clots.

For patients with pathology of homeostasis, the dosage is reduced. If blood clotting is poor, replacing Metronidazole with Tinidazole is generally undesirable.

Tinidazole reduces the speed of psychomotor reactions and affects concentration, so you should stop driving during the treatment period.

Metronidazole is available in several dosage forms: suspension, solution for infusion therapy, vaginal suppositories, tablets and gel. Tinidazole is only in tablet form, so metronidazole analogues in tablets cannot be used in local injection therapy.

Metronidazole is contraindicated in patients with a low white blood cell count and in pregnant women.

If absolutely necessary, Tinidazole can be used in the second and third trimesters. Breastfeeding is stopped when taking both drugs.

Source: https://dens1995.ru/desny/ciprolet-i-metronidazol-odnovremenno.html

Application

Quite often, doctors prescribe Metronidazole along with Tsiprolet. This is due to the fact that compatibility enhances the antimicrobial activity of drugs.

The following indications exist for the use of drugs in combination:

  • infectious and inflammatory processes in the gynecological area;
  • severe infections caused by anaerobic microorganisms;
  • infectious and inflammatory lesions of the peritoneum, severe, complicated by peritonitis.
  • infection with protozoa causing mixed abdominal infections.

Dosage and usage patterns

Combination therapy helps to increase the activity of the drugs used against a wide range of pathogens.

The combination of Tsiprolet with certain antimicrobial substances, for example, beta-lactam antibiotics, aminoglycoside drugs, as well as clindamycin and Metronidazole, significantly increases the effectiveness of the drug. That is why quite often doctors prescribe a treatment regimen in which it is necessary to take drugs at the same time.

For the treatment of infectious and inflammatory diseases, joint therapy with Metronidazole and Tsiprolet is prescribed.

For vaginal infections, it is possible to use suppositories or Metronidazole gel and Tsiprolet tablets.

Suppositories and gel are used intravaginally. Usually one suppository is prescribed per day (at night). The duration of the therapeutic course is 10 days. The standard dose of the gel is a full applicator or 5 g of active substance twice a day. The duration of treatment is 5 days.

If Metronidazole tablets are used, the standard dosage is as follows: 1 - 2 tablets (250 - 500 mg) should be taken 2 - 3 times a day. Duration of therapy is from 5 to 10 days.

Simultaneously with Metronidazole, it is necessary to drink Tsiprolet in the following dose: from 250 to 500 mg twice a day. The duration of the therapeutic course is from 7 to 10 days.

At the end of treatment, it is necessary to conduct an appropriate examination to ensure the effectiveness of the therapy used.

Found a mistake? Select it and press Ctrl + Enter

source: pillsman.org



The pharmaceutical medicine called ciprolet is an antimicrobial agent, and ciprolet is also an antibiotic.

Comparisons

In terms of pharmacokinetic parameters, Metronidazole is inferior to Ornidazole. The drug allows you to reduce the duration of therapy, while the therapeutic effect occurs much faster. The drug has better compliance and tolerability.

Therapeutic concentrations of Ornidazole in the blood remain long enough, which makes it possible to achieve complete elimination of urogenital trichomonas. Ornidazole does not interact with alcohol dehydrogenase in any way, so it is permissible to drink alcoholic beverages during the treatment period.

We suggest you familiarize yourself with How to rinse a tooth after extraction: so that it heals quickly

Domestic medicine allows the use of the drug during pregnancy. Ornidazole has a longer half-life (13 hours), binding to blood proteins does not exceed 15%. The bioavailability of drugs is approximately the same, but for Ornidazole it is at least 90%. How Metronidazole can be replaced and whether Ornidazole is suitable for this is decided only by the supervising physician.

There is no significant difference between the drugs. Indications for use are almost completely the same. However, Tinidazole enhances the effect of drugs that reduce the activity of the blood coagulation system and prevent excessive formation of blood clots. For patients with pathology of homeostasis, the dosage is reduced. If blood clotting is poor, replacing Metronidazole with Tinidazole is generally undesirable.

Tinidazole reduces the speed of psychomotor reactions and affects concentration, so you should stop driving during the treatment period.

Metronidazole is available in several dosage forms: suspension, solution for infusion therapy, vaginal suppositories, tablets and gel. Tinidazole is only in tablet form, so metronidazole analogues in tablets cannot be used in local injection therapy.

Metronidazole is contraindicated in patients with a low white blood cell count and in pregnant women.

If absolutely necessary, Tinidazole can be used in the second and third trimesters. Breastfeeding is stopped when taking both drugs.

Metronidazole has a more extensive list of side effects. It causes adverse drug reactions from the nervous system and digestive tract more often than Tinidazole. Tinidazole (from 30 rubles) costs 2-3 times cheaper than Metronidazole (from 80 rubles).

The synergy of these drugs makes it possible to achieve eradication of Helicobacter pylori. The penicillin antibiotic suppresses the development of immunity to Metronidazole.

To destroy Helicobacter pylori, you need to take 0.5 g of Metronidazole three times a day for seven days. To achieve a therapeutic effect, the supervising physician can adjust the dosage, taking into account the severity of the disease and concomitant pathologies.

The antimicrobial effect of Tsiprolet is enhanced when used together with β-lactam antibiotics and synthetic antibacterial agents. Metronidazole potentiates the action of Tsiprolet. A complex of two drugs is widely used in gynecological practice. Tsiprolet and Metronidazole are also effective in treating severe infections caused by anaerobes. In combination with Metronidazole, it is used for the treatment of intra-abdominal urgent conditions complicated by peritonitis.

Ciprofloxacin is a first-generation fluoroquinolone antibiotic. Its activity in the fight against infections caused by aerobic pathogens increases when used together with Metronidazole. Metronidazole and Ciprofloxacin are prescribed when the body is infected with protozoan microorganisms.

It is effective to combine cephalosporins and metronidazole.

Form of the drug and its composition

The drug ciprolet, its release form, comes in three types, these are:

  1. Pills. They are round, biconvex, covered with a white shell, like the core itself. They are sealed in a blister of ten pieces. One pack may contain one or two blisters.
  2. Solution for droppers (infusions). It is colorless and transparent. It is poured into plastic, one hundred milliliters each. In one package, one bottle, it is ready for use.
  3. Eye drops or ointment. The drops are also colorless. The bottle has a neck with a dropper, a capacity of five milliliters. One package contains one bottle.

Tsiprolet has its analogues.

Now let's look at the Tsiprolet product and its composition:

  • Tablets for oral administration.

The main substance is ciprofloxacin hydrochloride. Auxiliary components are various components. The shell consists of sorbic acid, hypromellose, polysorbate 80, talc, macrogol 6000, dimethicone, titanium dioxide.

The active ingredient is ciprofloxacin, but there are also additional components, including water for injection, and much more.

The main component is ciprofloxacin hydrochloride, there are also additional components.

This drug is excreted unchanged from the body through the kidneys, that is, with urine. Its complete removal from the blood takes approximately four hours.

In order to understand how to take the drug Tsiprolet, there are instructions for its use, which must be read before taking it.

After this, the patient will find out what exactly Ciprolet is prescribed for. In addition, Ciprolet is included in the RLS (register of Russian-made medicines).

You can’t prescribe a remedy for yourself if your friend has already taken it and it helped him.

When can you use the solution and Ciprolet tablets?

Tsiprolet has the following indications for use: inflammation in the body of an infectious nature, which appears due to the sensitivity of various microorganisms. But what are they from? They treat the following infections:

  • Oral cavity, teeth, stomach.
  • Ear, throat, nose.
  • Respiratory tract.
  • Gallbladder.
  • Urinary tract, kidneys.
  • Bones and muscles.
  • Skin, mucous membranes.
  • Postpartum trauma.
  • Infections of the genital organs.
  • Peritonitis.

In addition, the solution and tablet form of the drug are used in parallel when the infectious patient has low immunity.

Also, if a woman is diagnosed with cystitis, she is prescribed antibacterial therapy. Therefore, doctors recommend Ciprolet for cystitis in women. However, the remedy for cystitis should be taken only under the supervision of a doctor.

Many women ask the question: “Is Ciprolet an antibiotic medicine or not?” As mentioned earlier, this remedy belongs to the group of antibiotics.

Prostatitis will not go away either. Tsiprolet for prostatitis is prescribed if the cause of the disease is certain bacteria or streptococci. To destroy bacteria that cause inflammation in the pelvic organs, ciprolet is administered for prostatitis, bypassing the intestines. For example, these could be injections. When symptoms are relieved, it can be used orally. How many days the treatment will take is determined by the doctor.

You should also know that the drug ciprolet in the form of eye drops, as the instructions for use say, is prescribed for the treatment of eye inflammation due to bacteria, this is:

  • Conjunctivitis.
  • Blepharitis.
  • Ulcers of the cornea of ​​the eye.
  • Bacterial keratitis.
  • Chronic meibomitis and dacryocystitis.
  • Infection after surgery.
  • Possible complications after mote.

Drops also help when they are used before eye surgery.

If this drug is not suitable for treatment due to individual intolerance to some components, then do not forget that it has analogues.

Now it’s clear what this remedy helps with.

CIPROFLOXACIN

Name:

Lyubov Sergeevna
Review:
did not help

Name:

Mikola Vytrysoplenko
Review:
did not help

Name:

Lyubov Sergeevna
Review:
Severe cough, rapid fatigue and weakness did not go away for more than 10 days. I had this antibiotic at home that might help. After 7 days of taking ciprofloxacin there was no improvement and I went to a medical facility. Bronchitis was diagnosed and Flemoclav Solutab was prescribed. It belongs to the group of penicillins, which have a wider spectrum of action. It is better to go to a medical facility than to self-medicate. But sometimes work doesn’t allow(((((

Name:

ghhj
Review:
Ciprofloxacin is not a drug that treats the respiratory tract; it is more indicated for the treatment of purulent processes in soft tissues, urological pathology, and bile ducts. For the treatment of the tracheobronchial tree, so-called respiratory fluoroquinolones have been created, which include levofloxacin, moxifloxacin and gemifloxacin. And you are lucky with the flemoklav, because if your cough was caused by atypical flora (chlamydia, mycoplasma, etc.), it would not have helped. Therefore, of course, you need to see a doctor, and most importantly, a competent one...

Name:

Oksana Baskakova
Review:
a good remedy, it helped me with many diseases

Name:

Gulnora Juraeva
Review:
it helped me, it’s a good drug

Name:

Turbo Meow
Review:
A powerful antibiotic from the 90s. The price has dropped tremendously. Hehe, now let's test it on pigeons...

Name:

Love Deafness
Review:
I don’t know yet. Just started taking it.

Name:

Vladimir
Review:
Prescribed after tooth extraction

Name:

Marian
Review:
cured sinusitis. helped

Name:

Elina Kazis
Review:
I am in the hospital with an intestinal infection, this drug is given morning and evening, there seem to be no side effects)) even better)

Name:

lentochka
Review:
I was prescribed this drug after tooth extraction, on the second day after use I had a very headache! I just read the instructions and was dumbfounded by the side effects! I don’t take the drug anymore and don’t recommend it to anyone!!!!

Name:

Svetlana
Feedback:
My throat hurt .. the pain went away in the ear, I took various antibiotics for a month, nothing helped .. I took a sensitivity test and what kind of infection was in the throat .. they prescribed this drug for 5 days, it helped, no side effects.

Name:

Angelina Weiss
Review:
In fact, it is a controversial drug, like any other antibiotic. I took it myself for a sore throat, and it helped a lot. And my husband was prescribed it for prostatitis - we don’t see any effect, that’s all. And this despite the fact that he is being treated with smartprost at the same time. It feels like we missed the mark. But the doctor assures us that “we have to wait.” And how long to wait, one wonders?

Name:

Galina Vesnichenko
Review:
In fact, it is a controversial drug, like any other antibiotic. I took it myself for a sore throat, and it helped a lot. And my husband was prescribed it for prostatitis - we don’t see any effect, that’s all. And this despite the fact that he is being treated with smartprost at the same time. It feels like we missed the mark. But the doctor assures us that “we have to wait.” And how long to wait, one wonders?

Name:

Pavel Logunov
Review:
Yes, it helps a lot. The only thing I don’t like is that you need to drink it for a long time; in the second week, your stomach often still hurts. BUT in general, if combined with other medications, smartprost, massage, etc., the effect is quite lasting, unlike other antibiotics.

Name:

Lyolik
Review:
By the way, there are now excellent suppositories for prostatitis. The stomach does not hurt, but the intestines are a little seething. It's called Langidase. Only expensive. But it's effective. It's worth it.

Name:

Elizarova Yana
Review:
I have a chronic adenoma. I was prescribed: furamag, nitroxoline, ciprofloxin, doxazosin finasteride, vitaprost. Question: Can all this be taken in one day????

Name:

Oleg Porshnev
Review:
I’m going to take the drug for 4 weeks, I got it, it’s true, it’s made in Russia?

Name:

Anton Ilyinykh
Review:
treated sinusitis. helped

Contraindications

Tsiprolet has its contraindications, these are:

  • You should not drink Ciprolet during pregnancy.
  • Patients intolerant to one of the components of the drug.

Under strict medical supervision, you should drink Ciprolet during atherosclerosis, poor circulation and convulsions.

It should also be understood that each form of the drug has its own contraindications, so people taking the medicine on their own can greatly undermine their health.

For example, tablets and solution cannot be taken for pseudomembranous colitis and under eighteen years of age; this medicine is prescribed only to adults. This form of the drug is recommended with caution to people with various disabilities, as well as elderly patients.

It is not recommended to use drops if the patient has viral keratitis, as well as for children under one year of age.

Doses of the drug and its use

The medicine Tsiprolet has different methods of use, depending on the form of release.

  • Tablets for oral use.

They must be drunk on an empty stomach (that is, before meals), washed down with a suitable amount of water. The dosage and how many days the therapy will take is determined by the doctor individually. Taking into account the indications, type of pathology, chronic pathologies, severity of the disease, the patient’s age and weight.

For the treatment of certain pathologies, the following proportions are recommended:

  • For infections of the kidneys, respiratory tract, and genitourinary system of various forms: mild - ciprolet 250 mg, severe - ciprolet 500 mg, taken twice.
  • For gonorrheal disease - 250 mg or 500 mg, at a time, before meals.
  • Severe infectious gynecological diseases, prostatitis. You need to take the medicine twice a day in a proportion of 500 mg.
  • Diarrhea - twice, 250 mg.

Therapy lasts one and a half weeks. When the symptoms completely disappear, you need to take the medicine for a couple more days.

If the signs of kidney disease are too pronounced, then the dose of the drug should be halved, as the instructions say.

If renal failure is a chronic pathology, then the dose will depend on creatinine clearance.

  • Solution for intravenous infusion.

This drug is injected into a vein by drip; for this, it must be mixed with other solutions. The dosage is also calculated taking into account all the patient’s indications.

The duration of administration is calculated so that 200 mg is infused in half an hour.

For different severity, their proportions are prescribed, for example: moderate - 400 mg, twice a day, severe - 800 mg, twice. Treatment requires fourteen days, in some cases more.

Acute form of gonorrhea, treated with 100 mg solution, once.

To prevent infection from occurring after surgery, use 200 mg half an hour before the start of the intervention.

Drops are used by instilling into the sore eye. The dose also depends on the severity of the disease: mild and moderate form - two drops four times a day, severe form - two drops hourly. As soon as the patient's condition has improved, the dose and frequency are reduced.

When a patient is diagnosed with a corneal ulcer, the treatment regimen is unique. It is developed by the doctor who treats the patient.

Ciprofloxacin or metronidazole, which is better – All about parasites

Have you been trying to get rid of PARASITES for many years?
Head of the Institute: “You will be amazed at how easy it is to get rid of parasites by taking every day...

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Many protozoan parasites die only under the influence of antibacterial agents. For example, when treating giardiasis or amoebiasis, it is advisable to use exclusively antibiotics. It is not advisable to use anthelmintic drugs when infected with protozoan parasites.

The best antibacterial medications are Metronidazole and Trichopolum. These drugs have high bioavailability. The drugs are active against protozoan parasites and bacteria.

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A significant advantage of Metronidazole, Trichopolum and other similar drugs is their low toxicity rates. That is why these parasite remedies are widely used even in the treatment of children.

The difference between Trichopolum and Metronidazole

What is the difference between Trichopolum and Metronidazole? These medications are analogues. The drugs contain the same active substance – metronidazole. This chemical compound is a derivative of 5-nitroimidazole. The active component is able to resist some parasites, protozoan microorganisms and anaerobic microorganisms.

In fact, Trichopolum is an analogue of Metronidazole. However, there are minor differences in the drugs. For example, Trichopolum contains potato starch, gelatin and starch syrup. The instructions for use of Metronidazole state that it contains inactive substances such as starch, stearic acid and talc.

The principle of action, pharmacokinetics, indications and contraindications for use of the drugs are absolutely identical. A completely logical question arises: “Is it possible to replace Metronidazole with Trichopolum?” This can be done, since there are no significant differences between the drugs.

Mechanism of action and purpose of drugs

As noted above, the difference between the drugs is insignificant. That is why the instructions for using the drugs are identical. The active substance of these medications interacts with the DNA of parasites, thereby inhibiting the synthesis of essential nucleic acids. Under the influence of this process, the processes of cellular respiration of the protozoa are disrupted, and they die.

It is noteworthy that the active substance Trichopolum and Metronidazole have the highest bioavailability. Thanks to this, the metabolites of the drug are well absorbed in the gastrointestinal tract, and the therapeutic effect occurs quickly.

According to the instructions, the drug begins to act actively a few hours after taking it.

The speed of onset of the therapeutic effect may vary - everything will depend on the individual characteristics of the person. A small part of the metabolites is bound to plasma proteins.

The remaining part (approximately 80%) is absorbed in the gastrointestinal tract. Inactive metabolites of medications are eliminated through the kidneys and intestines.

In what cases can Metronidazole and Trichopolum be used? Indications for use are the following diseases:

  1. Intestinal and extraintestinal forms of amoebiasis.
  2. Giardiasis.
  3. Amoebic liver abscess.
  4. Trichomonas urethritis and vaginitis.
  5. Leishmaniasis.
  6. Amoebic dysentery.
  7. Infections of the central nervous system, joints and pelvic organs that appear as a result of infection with anaerobic bacteria, peptostreptococci or clostridia.
  8. Chronic ulcerative diseases that arise due to infection with the bacterium Helicobacter pylori.

Instructions for use of drugs

How to take Metronidazole and Trichopol tablets? The instructions for use state that the treatment regimen remains unchanged. Everything will depend only on the age of the patient and the type of disease.

When treating amebiasis, amoebic dysentery or amoebic abscess, the daily dosage is 250-500 mg (for children under 12 years of age), and 1.5 grams for adults. In cases of acute disease, the daily dose can be increased by 35-50%.

When treating giardiasis and other parasitic diseases, the dosage is 250-750 mg for children and about 1-1.5 grams for adult patients. The duration of treatment usually does not exceed 8 days. However, if necessary, therapy is carried out in several courses. In this case, it is necessary to maintain an interval of 20-35 days.

The difference in the drugs is insignificant, so they have similar contraindications. Antibiotic medications should not be used in the first trimester of pregnancy and during the lactation period.

This is due to the fact that a small part of the active metabolites is absorbed in the placenta and passes into breast milk.

Also contraindications for use are:

  • Allergy to metronidazole or auxiliary components of the drug.
  • Organic lesions of the central nervous system.
  • Acute liver failure. Also, these antibiotics should not be taken if a person suffers from chronic liver diseases.
  • Disturbances in the excretory capacity of the kidneys.
  • Leukopenia.

While taking Trichopolum or Metronidazole, it is strictly forbidden to drink alcoholic beverages. Also prohibited are anticoagulants, Phenytoin, Phenobarbital. It is highly not recommended to take Vecuronium bromide during the course of treatment.

Recent clinical studies have revealed that the combination of metronidazole-based antibiotics and non-depolarizing muscle relaxants can lead to the development of undesirable complications.

When using Trichopolum or Metronidazole, the following side effects may occur:

  1. Stool disorders, stomatitis, glossitis, jaundice, pancreatitis, vomiting, abdominal pain.
  2. Nasal congestion.
  3. Chills, convulsions, tremors of extremities, disorientation, sleep disturbances, decreased concentration.
  4. Decreased libido (more often observed in men).
  5. Arthralgia.
  6. Allergic reactions.
  7. Pallor of the skin.
  8. Leukopenia, agranulocytosis, neutropenia.
  9. Decreased blood pressure.
  10. Sinusitis.
  11. Dysuria, polyuria, cystitis, urinary incontinence.

The best analogue of medicines

What to do if Metronidazole and Trichopolum are contraindicated? In this case, the attending physician must select a possible analogue with a similar mechanism of action. Reviews from doctors indicate that the best analogue of Trichopolum and Metronidazole is Furazolidone (50-60 rubles).

This antibiotic has a similar mechanism of action. The drug has a good bioavailability (70-80%). The medicine has similar indications for use

To remove parasites and bacteria, daily use of 200-800 mg of Furazolidone is indicated. The duration of the course of treatment is 5-7 days. The medication is contraindicated for:

  • Pregnancy.
  • Breastfeeding.
  • Lactase, liver or kidney failure.
  • Allergies to its active components.

Also contraindicated for use is children (under 8 years). When using an antibiotic, complications from the digestive, nervous, hepatobiliary and immune systems may develop. There is also a risk of developing allergic reactions, hypoglycemia and arterial hypotension.

In the video in this article, the doctor will consider the spectrum of action of Trichopolum and its effectiveness against parasites.

  • Trichopolum suppositories: instructions for use in gynecology, price and reviews
  • Tinidazole or Metronidazole: which is better and what is the difference between the drugs?
  • Pinworms and Ascarids: difference and photos, symptoms and treatment

Source: https://analiz.glistus.ru/parazity/tsiprofloksatsin-ili-metronidazol-chto-luchshe/

Possible side effects

Tsiprolet has side effects that differ depending on the form of the drug.

  • Tablets for oral use and solution for droppers.

Since ciprolet is a medicine, in case of infectious pathologies of various body systems, it can cause the following phenomena:

  1. Nervous system: headache, dizziness, weakness, tremors in the limbs, lack of sleep, anxiety, nightmares, increased sweating, high blood pressure, depression, fainting and much more.
  2. Digestive system: nausea, vomiting, diarrhea, bloating and others.
  3. Sense organs: impaired taste, incorrect perception of smells, tinnitus, hearing loss.
  4. Blood: anemia, thrombocytosis, leukocytosis.
  5. Heart and blood vessels: decreased blood pressure, irregular heartbeat, tachycardia, hot flashes.
  6. Bones and muscles: arthritis, tendon ruptures and more.
  7. Genitourinary system: urinary retention, hematuria, bleeding from the urethra and others.
  8. Laboratory indicators: changes in normal values.
  9. Allergies: shortness of breath, itching, swelling of the face and throat, vasculitis, photophobia, Lyell's syndrome, blisters on the skin.
  10. General malaise.
  11. Eye drops.

When using drops, the following complications in the organs of vision may occur: slightly noticeable pain, conjunctivitis, burning, itching, swelling of the eyelids, loss of vision and much more.

In addition, other side effects may occur, such as nausea, allergies.

There are also other side effects, such as a bad taste after using the medicine.

Special Recommendations

If a patient is diagnosed with special pathologies of the nervous system, such as seizures, epilepsy, pathologies of blood vessels, then Ciprolet should be used according to indications.

Now let's look at whether it is possible to drink alcohol while being treated with this remedy? The answer is simple, it is impossible to combine ciprolet and alcohol, because the effect of alcoholic beverages is almost the same as the effect on the body of this drug. But if it so happens that you mixed Ciprolet and alcohol, then after taking it, expect side effects such as nausea, vomiting, tremors in the limbs, anxiety, depression, nightmares and much more. Therefore, try not to combine Ciprolet with alcohol.

If a patient experiences prolonged diarrhea while using this drug, they should be checked for pseudomembranous colitis. If the diagnosis is confirmed, then the use of the solution or tablets should be stopped immediately.

Also, you should not use these forms of the drug in the future if the first symptoms of tendon rupture appear.

The use of tablets and solution must be combined with large fluid intake. However, this is only possible if the patient has normal urination.

During the entire course of therapy, you should not sunbathe and stay in the sun for a long time.

You should also give up contact lenses.

If you use two different eye drops, then take a short break between procedures, at least five minutes, or even more.

Please note that this remedy affects the reaction, so you should not drive a car or use other machinery during therapy.

Interaction with other medications

You need to know that the medicine Ciprolet is prescribed with caution if another group of antibiotics is used, because it is also classified as an antibiotic. In addition, it is necessary to warn the doctor, saying that I am taking this or that drug.

The compatibility of Ciprolet with other medications varies, so you need to know which one is not allowed, for example:

  • Didanosine. After it, ciprofloxacin is poorly absorbed.
  • Theophylline concentrates the drug too much in the blood, causing poisoning.
  • Medications containing zinc, magnesium, iron, aluminum ions, on the contrary, interfere with the absorption of the drug, so you need to take a break between taking them. But how long after you can drink them is after at least four hours. Thus, their compatibility will not have a negative impact on the body.
  • Cyclosporine will increase the negative effect on the kidneys.
  • Other anti-microbial medications will enhance their effects together with Ciprolet.
  • Nonsteroidal medications that reduce inflammation will increase the risk of seizures.

It is also worth using other drugs carefully, especially without knowing their compatibility.

In the case of individual infections, there is a possible combination of the following combinations of drugs:

  • Streptococcal. Mezlocillin, Azlocillin and another drug called an antibiotic.
  • Staphylococcal. Vancomycin.
  • Anaerobic. Metronidazole, clindamycin.

Their compatibility with Ciprolet is justified.

Comparison of prices for CIPROFLOXACIN and METRONIDAZOLE

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