Metrogyl Denta during pregnancy - is it worth using?

Contraindications

Contraindications to the use of the gel for therapeutic purposes for pregnant women are:

individual intolerance to components;
first trimester of pregnancy;
gingivitis;
age less than 18 years;
diseases of the circulatory system;
diseases of the central and peripheral nervous system.

What does Metrogyl help with? According to the instructions, the gel for external use is prescribed in the following cases:

rosacea (including post-steroid acne), acne vulgaris;
infectious skin diseases, bedsores;
burns;
eczema, seborrheic eczema, oily seborrhea, seborrheic dermatitis;
trophic ulcers of the lower extremities (against the background of varicose veins, diabetes mellitus), slow-healing wounds;
hemorrhoids, anal fissures.

Vaginal gel is used to treat bacterial vaginitis and trichomoniasis.

The use of Metrogil Dent gel, especially in the initial stages of treatment, can cause bleeding gums, increased swelling and burning. Such symptoms may appear within a few days, but if they continue, you should stop using the drug.

children under 6 years of age;

women in the first trimester of pregnancy,

In addition, it is not advisable to use the drug while breastfeeding and, if it is necessary to use it, you will have to stop breastfeeding.

Many experts recommend avoiding drinking alcohol during treatment with Metrogyl gel, since it contains an antibiotic that can be absorbed into the blood, even when applying applications.

In addition, the use of the drug should be discontinued at the first signs of intolerance to the drug.

Studies have shown a negative effect of the drug when taken together with anticoagulants, since the active substances of Metrogyl can enhance their effect, which can cause bleeding.

Like any medicine, Metrogyl Denta dental gel has its own characteristics when used during pregnancy:

First of all, it is necessary to understand that the use of Metrogyl Denta gel cannot replace daily oral care;
When using the dental drug MetrogilDenta, you must thoroughly brush your teeth twice a day, choosing the right toothbrush and toothpaste;
If the oral cavity of a pregnant woman requires additional care, then additional brushing of the teeth and rinsing of the mouth with special means are possible;
When using Metrogyl Denta dental gel during pregnancy, you must carefully ensure that the gel is not accidentally swallowed: if swallowed, this drug can cause dizziness, as well as nausea and even vomiting, which is explained by the action of Metronidazole, since Chlorhexine enters the gastrointestinal tract , is not absorbed and does not enter the bloodstream;
If a pregnant woman nevertheless swallows the gel, she urgently needs to rinse her stomach;
For MetrogilDent gel to be as effective as possible, it should be applied to the gums twice a day - in the morning and in the evening after brushing your teeth;
Before applying dental gel to the gums, it is necessary to rid the oral cavity of saliva and possible mucus;
To thoroughly dry the mouth before using dental gel, you can use sterile wipes and/or breathe through your mouth;
As a rule, MetrogilDent dental gel is applied to the outer and inner surfaces of the gums, but in some cases the product is also applied to the inner surface of the cheeks (on the mucous membrane);
The drug is applied to all necessary areas using a cotton swab, cotton swabs or fingers (hands should be thoroughly washed before applying the drug);
After MetrogilDent gel has been applied to the gums and other areas of the oral cavity, you should not drink or put any liquid into your mouth for at least 30 minutes;
You can eat food after applying the gel no earlier than three hours;
After applying the drug MetrogilDenta, you should spit rather than swallow saliva;
The duration of use of the drug during pregnancy should not exceed ten days, although in other cases it may be a little longer (as prescribed by a doctor);
After the expiration date, the drug must not be used;
When treating with MetrogilDent gel, the use of any alcohol-containing drugs or the consumption of even the lightest alcoholic beverages is strictly prohibited.

If there is any doubt or any side effects, a pregnant woman should immediately inform both her dentist and her doctor who is monitoring the pregnancy. It is possible that the drug can be canceled or replaced with another drug.

Precautionary measures

Metrogyl Denta is prohibited from use in the following cases:

Hypersensitivity to the main or auxiliary components;
Up to 12 weeks of pregnancy;
Children under 6 years old.

The drug is used by lactating women under the supervision of a physician.

Negative phenomena occur only if the patient has contraindications:

itching;
skin rash;
nettle fever;
headache.

With excessive consumption, negative effects due to the effects of metronidazole are more pronounced. Then the patient feels pain and dizziness, feels nauseous, has periodic bouts of vomiting, and skin sensitivity is impaired (tingling, numbness). After the appearance of such symptoms, gastric lavage and symptomatic treatment are performed.

Stress, pregnancy and the occurrence of dental pathologies

Early dental intervention is the best way to monitor oral health and prevent the development of dental pathologies. Unfortunately, going to the dentist does not cause the most pleasant associations for pregnant patients, and they postpone it until the moment when the disease has already developed so much that it becomes impossible to fully eat.

During pregnancy, teeth deteriorate much faster also due to the enormous need of the fetus for calcium. If the mother’s body has not accumulated a sufficient supply of the mineral, then she will have to spend everything she has for the sake of the child - including her own teeth.

Anything can be a stressful situation for a pregnant woman, including pregnancy. So many changes at once (and hormonal changes especially) cannot but affect your health. And if before pregnancy a woman did not carefully monitor the condition of her oral cavity, then during pregnancy this can come back to haunt her very badly - “small” caries quickly turns into large ones, and dental infectious diseases can occur against the background of a weakened immune system.

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Use during pregnancy

When pregnancy occurs, the concentration of hormones in a woman’s blood sharply increases, which accumulate, including in the gum tissue. Some types of bacteria tend to consume female hormones instead of the usual products necessary for their vital functions, thereby supporting their growth.

Also, during pregnancy, the acidity (pH) of saliva decreases, its antibacterial and enzymatic properties decrease, which leads to an increased risk of developing stomatitis, gingivitis and caries. The instructions for Metrogyl Dent indicate a combination of chlorhexidine and metronidazole, which is reasonable, since these two substances specifically act on those microorganisms that damage the oral mucosa mainly in pregnant women.

Stomatitis most often has a viral (aphthous) or fungal (candida) etiology. The use of Metrogyl Dent during pregnancy is justified if it is necessary to prevent the addition of a bacterial or fungal infection, since a viral infection suppresses local immunity and the body's resistance to bacteria decreases.

The gel is quite effective: in most cases (almost 95% of patients), the ulcers disappear after two to three days of use. In order for the effect to be long-lasting, a course of treatment lasting at least 10 days is required.

Metrogil Denta by trimester

1st trimester

The drug is contraindicated due to the poor protection of the fetus and the maternal body. Alternative methods are recommended: rinsing, other medications. Treatment with such methods most likely will not give the desired result, but will somewhat alleviate the patient’s condition.

2nd trimester

The use of Metrogyl Dent is possible under the supervision of the attending physician. The duration of the course of therapy is no more than 10 days. If after this time there is no effect, the drug should be discontinued.

3rd trimester

Metrogyl gel is prescribed according to indications for a period of 7-10 days.

MetrogilDent dental gel, like any drug, cannot be used in the first trimester of pregnancy. However, inflammatory processes in the oral cavity are also possible during this period, especially since the woman’s body is weakened by active hormonal changes, which are accompanied by a drop in immunity.

Of course, when planning a pregnancy, a woman should definitely visit the dentist so that the oral cavity does not cause any concern during pregnancy, but the occurrence of inflammatory processes is not excluded.

If the inflammatory process in the oral cavity does begin during the first trimester of pregnancy, then the use of any medications during this period will have to be decisively abandoned.

However, what measures can be taken to get rid of discomfort and pain?

First of all, you need to visit a dentist, who needs to be informed about the pregnancy and its duration, so that the specialist can select a possible treatment that will definitely not harm the developing embryo or fetus. The dentist will be able to offer some alternative solutions that will be completely safe for both the expectant mother and the developing child.

If the use of medications seems impossible, the dentist may recommend rinsing the mouth with decoctions of medicinal herbs, using applications of herbal decoctions or other natural remedies, for example, bee products.

Potential Harm

During pregnancy, you can use Metrogyl Denta after the end of the first trimester. According to the results of clinical studies, it is safe during this period for the intrauterine development of the fetus.

Is Metrogyl Denta allowed for pregnant women?

The drug Metrogyl Denta is used for two purposes:

For the prevention of dental diseases.
For temporary relief of the patient’s condition, in the absence of the possibility of urgent dental intervention.

That is, the second option for use for pregnant women would be ideal, if not for one thing: the drug cannot be used in the first trimester, and in subsequent trimesters it should only be used as prescribed by a doctor and with great caution.

There is nothing new in this system of approach: any of the drugs can pose a potential threat to the fetus, so it is better to protect yourself and your unborn child and refrain from therapy with potent drugs if there is the possibility of alternative treatment.

If there is none, you must seek medical advice and use Metrogyl Denta in strictly dosed doses according to the regimen developed by the attending physician for an individual course of therapy.

Drug interactions

Analogues of Metrogyl gel are drugs that also contain metronidazole as the main substance. These drugs belong to the clinical and pharmacological group of antiprozoal drugs with antibacterial activity.

Analogs of Metrogyl gel for the treatment of acne: rozamet, rosex gel, metroseptol gel.

The following groups of antibiotics are most often used to treat acne: lincosamides and macrolides. Examples include the antibiotics Clindamycin and Erythromycin. They most often come in the form of topical gels (less commonly, liquids) that are applied directly to the affected areas of the skin.

Examples of monocomponent drugs -

gels based on clindamycin - “Dalacin”, “Klindatop”, “Klindovit”...
based on erythromycin - the drug "Zinerit" (this drug is available in the form of a liquid applied to the skin using an applicator).

Combination drugs will contain, in addition to the antibiotic, another active component, which expands their effectiveness and possibilities of use. Typically, in the composition of such gels, the antibiotic is combined with benzoyl peroxide or retinoids.

The combination of an antibiotic with benzoyl peroxide dramatically increases the effectiveness of the gel and the speed of onset of the effect. This combination is also prescribed for acne, but in the absence of acne and cysts on the skin.

Duak-gel (antibiotic clindamycin benzoyl peroxide),
Deriva-S, Klenzit-S (antibiotic clindamycin retinoid Adapalene),
Isotrexin gel (antibiotic erythromycin retinoid Isotretinoin).

The drug "Metrogyl" (intravenous) is an antimicrobial and antiprotozoal agent. The active substance of the drug is metronidazole. The drug exhibits activity against a number of gram-positive bacteria and obligate anaerobes.

When 500 mg is infused over 20 minutes, the maximum level of the drug in the blood is observed after an hour. About 30-60% of the product is metabolized. The main metabolite has antimicrobial and antiprotozoal effects. About 60-80% is excreted in urine, and up to 15% of the drug is excreted in feces.

Purpose

The drug is indicated for the treatment and prevention of infectious lesions caused by sensitive microbes. In particular, the medicine is recommended for surgical interventions in the urinary tract and abdominal organs.

Application diagram

The initial dosage for patients over 12 years of age is from half to one gram dropwise. The duration of the infusion is thirty to forty minutes. Every next 8 hours the medicine is administered at a dose of 500 mg.

The infusion rate is 5 ml/min. With satisfactory tolerability, after the first 2-3 infusions, jet administration is used. Duration of therapy is a week. No more than 4 g per day is allowed.

For patients under 12 years of age, the drug “Metrogyl” (intravenously) is prescribed according to the indicated regimen in a single dosage of seven and a half milligrams/kg. To prevent complications during surgical interventions, patients over 12 years of age are prescribed 0.5 to 1 g per day before surgery and 1.5 g/day the next day.

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(0.5 mg every 8 hours). When used as a radiosensitizing agent, administration is carried out dropwise at 160 mg/kg or from 4 to 6 g/m2 of body surface. The infusion is made half an hour to an hour before irradiation.

As practice shows, if the infusion rate and dosage schedule are observed, undesirable consequences rarely develop. According to the observations of specialists, patients tolerate the therapy satisfactorily.

With simultaneous use, metronidazole potentiates the effect of warfarin and other indirect anticoagulants and increases prothrombin time.

With the simultaneous use of disulfiram and metronidazole, the development of acute psychosis and disorientation is possible.

With short-term use of metronidazole during treatment with lithium salts in high doses, it is possible to increase the concentration of lithium in the blood plasma, increase its toxicity and cause symptoms of renal dysfunction.

With the simultaneous use of metronidazole with astemizole and terfenadine, ECG changes, arrhythmias, heart block, and fainting are possible.

When metronidazole is used concomitantly with cimetidine, the metabolism of metronidazole in the liver may be reduced, which may lead to delayed elimination and increased plasma concentrations of metronidazole.

With the simultaneous use of metronidazole and phenytoin, a decrease in clearance and an increase in the concentration of phenytoin in the blood plasma is observed.

Composition and effect of the drug

Metrogyl Denta was developed by Indian pharmacists using recipes and Ayurvedic experience and, as they say, under strict control of all stages of the preparation, starting from the cultivation of raw materials.

Active ingredients: metronidazole benzoate, chlorhexidine bigluconate.

The drug is produced in the form of a white gel.

An antiseptic and antimicrobial agent (antibiotic), which, when used topically, is practically not absorbed and does not enter the bloodstream.

Metrogyl Denta is active against gram-positive and gram-negative bacteria, but does not interfere with the functional activity of lactobacilli.

gingivitis;
stomatitis;
periodontitis and periodontal disease;
cheilitis.

Contraindications to the use of the drug in the instructions indicate individual intolerance and pregnancy (1st trimester).

Application diagram

Metrogyl gel against acne or in the treatment of vaginal pathologies has an antimicrobial effect. It is capable of killing parasites that develop without oxygen. The product can infect the following types of microbes:

mobiluncus;
eubacterium;
clostridium;
bacteroides;
peptostreptococcus.

Metrogyl is effective against the following protozoa:

Giardia intestinalis;
Gardnerella vaginalis;
Trichomonas vaginalis.

Metrogyl exhibits activity against pathogens at the cellular level, inhibiting the synthesis of nucleic acids in bacterial molecules. This mechanism of action helps the drug effectively resist infectious diseases. There is a gel for external use against acne and a vaginal version to combat urogenital pathologies. Metrogyl Denta was created for dental needs.

Description of the drug

Metrogyl Denta is produced by an Indian pharmaceutical company that uses Ayurvedic knowledge when developing its drugs.
The release form of the medicine is a white gel with a faint menthol odor. The basic components of the product are chlorhexidine and metronidazole. Additional components:

Sodium hydroxide
Levomenthol
Saccharin
Carbopol
Water
E 1520.

https://www.youtube.com/watch?v=wJEe7SZeKB8

Metrogyl Denta is an antimicrobial and antiseptic drug. When applied topically, the gel is almost not absorbed and does not penetrate into the general bloodstream.

The antibiotic effectively destroys gram-negative and gram-positive microorganisms. However, the drug does not disrupt the microflora in the mouth. Therefore, the number of lactobacilli does not decrease.

Metrogyl denta is prescribed for the following diseases:

Periodontitis is inflammation of the periodontium, leading to the appearance of a pocket in the gum and destruction of the bone process
Gingivitis – occurs due to hormonal imbalance, lack of vitamins in pregnant women
Aphthous stomatitis - the disease is characterized by the formation of aphthae, the ulcers hurt and take a long time to heal
Cheilitis – characterized by the formation of ulcerations, crusts, and redness in the corners of the mouth
Periodontitis – inflammation and suppuration of the periodontium
Periodontal disease is a lesion of the tissues that fix the tooth, which exposes the neck of the tooth.

Doctors know whether Metrogyl denta gel can be used topically for dental diseases by pregnant women. But contraindications should be taken into account. These are intolerance to components, age under 18 years, diseases of the central nervous system or blood, 1st trimester of pregnancy.

Using Metrogyl may lead to side effects. Often, after using the gel, allergic manifestations and headaches appear.

Instructions on how to take

After a woman finds out about pregnancy and registers with the antenatal clinic, she has to radically change her lifestyle. For example, if any symptoms occur, you can no longer go to the pharmacy and buy the usual pill, because now the woman is responsible not only for herself, but also for the fetus.

In 1st trimester

The embryo grows actively in the first trimester. By the end of the 12th week, a fertilized egg produces a tiny embryo that has germ layers of almost all major organs. You cannot interfere with this process, otherwise any third-party components and substances can cause irreversible changes and lead to congenital anomalies.

The most common interventions, of course, are medicinal, so doctors prohibit almost all pharmaceutical products in the first trimester. Metrogyl denta also falls into this list: under no circumstances should it be used in the early stages, like any other gels for the oral cavity. The fact is that Metrogyl denta contains substances whose properties are similar to antibiotics, the use of which is contraindicated for expectant mothers in cases where there is no threat to life.

In the 2nd trimester

In the second trimester, the list of permitted medications expands: the main and most difficult stages of the baby’s development are behind, the fetus is protected by the placenta, and the uterus becomes less susceptible to various types of influences. During the period from the 13th to the 27th weeks of pregnancy, a woman regularly visits the dentist.

Unfortunately, at this time, many expectant mothers are diagnosed with some kind of dental or gum disease. In this case, the doctor may prescribe various rinses, gels, and even offer treatment using local anesthesia. But Metrogyl denta is still a prohibited drug.

In the later stages

At the final stage of pregnancy, no dental procedures are performed, because stress is extremely undesirable for the expectant mother’s body and can lead to premature birth.

The permissible maximum is antibacterial rinses and safe mouth gels. Metrogyl denta is also prohibited in the third trimester. Despite this categorical attitude of specialists towards this drug, it is sometimes prescribed during pregnancy in the second and third trimesters. This is done after assessing the condition of the oral cavity, making a diagnosis and treatment with other, alternative drugs.

When analogues turn out to be ineffective, and treatment is impossible for some reason, the doctor may prescribe Metrogyl denta in the 3rd trimester, if there is a threat of tooth loss or the woman experiences unbearable discomfort.

In particular, indications for using the gel during pregnancy are:

Vincent's ulcerative-necrotizing gingivitis;
post-extraction alveolitis;
acute or chronic periodontitis;
cheilitis;
stomatitis.

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If infectious and inflammatory diseases of the oral cavity are detected, the dentist may prescribe Metrogyl dent in minimal doses for a short course. As a rule, the duration of use during pregnancy does not exceed 10 days.

The gel is applied in a thin layer to the oral mucosa (gums, cheeks, palate, if necessary) 2 times a day: morning and evening after brushing your teeth. This can be done with your finger, after washing your hands, or with a cotton swab. After applying the gel, you should not eat or drink for 30-40 minutes.

Instructions for use

The use of medications during pregnancy must be agreed with a doctor. In the absence of adequate treatment, even a harmless infection with a high probability can provoke intoxication and painful symptoms. Obviously, these processes can be dangerous not only for the health of the expectant mother, but also for the fetus.

Metrogyl gel is evenly distributed over the problem area in a thin layer

Instructions for use:

The oral cavity is rinsed with a decoction of chamomile or oak bark.
A small amount (0.5-1 g) of the drug is applied to a cotton swab.
Using a cotton swab or swab, treat problem areas of the mucous membrane.
The product is applied in a thin layer, evenly distributed over the affected area.
The duration of the procedure depends on the characteristics of the pathological process, the characteristics of the patient’s body, and the doctor’s recommendations.

The listed manipulations are safest to carry out in the third trimester, when the fetus is sufficiently mature and the active substances of the drugs do not affect its development. The duration of treatment for periodontal diseases varies from 5 to 10 days.

Indications and contraindications

Experts recommend not using Metrogyl for prophylactic purposes. The use of the medication during pregnancy is possible only for health reasons, due to the lack of clinical studies. The dosage and frequency of administration are determined by the doctor for each individual patient.

The drug is prescribed for the following diseases:

cheilitis – formation of cracks in the corners of the mouth, red crust on the lips;
abscesses (limited peritonitis);
aphthous stomatitis – ulcerative lesions of the oral mucosa;
periodontitis is a disease of inflammatory etiology, localized in soft tissues, accompanied by the formation of suppuration;
Gingivitis in pregnant women is an inflammation of the gums that occurs against the background of hormonal changes in the body.

Metrogyl gel is exceptionally tolerable, however, the drug is not suitable for some patients. The drug is contraindicated for use in case of individual intolerance, incl. individual components. It does not recommend its use during breastfeeding, since no studies have been conducted on the effect of active substances on mother's milk.

Scheme of use during pregnancy

During pregnancy, the gel is applied in a thin layer to the affected areas of the mucous membrane. For minor pathologies, 0.5 g of medication is sufficient for 1 procedure. Repeat frequency: 2 times a day. Adult daily dosage is from 0.5 to 2 g, in accordance with the doctor’s recommendations.

The maximum duration of therapy is 10 days. The specified period is sufficient for the treatment of most dental pathologies. If a woman is diagnosed with trichomonas colpitis, the treatment regimen is selected individually. The decision to stop or prolong taking the drug is made by the attending physician, not the patient.

Use during breastfeeding

Metrogyl is a local drug, which involves local treatment of problem areas. The active components of the drug practically do not enter the main bloodstream. But doctors do not recommend using the gel while breastfeeding.

Side effects

The use of Metrogyl gel is allowed from the 2-3 trimester of pregnancy as prescribed by the attending physician and under his supervision. In rare cases, against the background of hormonal changes, the medication can provoke allergic reactions in the form of itching, burning or swelling of the affected area.

For what diseases can pregnant women use METROGYL DENTA ®

Gingivitis in pregnant women is an inflammation of the gums that develops against the background of hormonal changes and hypovitaminosis, in which the dentogingival attachment maintains its integrity.
Periodontitis is an inflammatory process in periodontal tissues, causing destruction of the alveolar process and the formation of a gum pocket.
Periodontal disease is a non-inflammatory lesion of periodontal tissue, characterized by exposure of the neck of the tooth without the formation of a gum pocket.
Periodontitis is an inflammation of periodontal tissues (near-root tissues and the root membrane of the tooth), in which suppuration appears in the affected area.
Aphthous stomatitis is a disease of the oral mucosa, which is characterized by the formation of painful and poorly healing ulcers (aphthous ulcers).
Cheilitis is a disease in which cracks appear in the corners of the mouth, redness of the red border of the lips is observed, and crusts form on them.

Symptoms

Typically, symptoms of gingivitis occur in the 3-4th month of pregnancy, since during this period intense hormonal changes occur, leading to the development of the catarrhal form of the disease. Gingivitis manifests itself as follows:

bleeding gums;
pain when brushing teeth;
swelling of the marginal part of the gums and gingival papillae;
change in gum color (first redness, then blueness).

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Inflammation, accompanied by swelling and bleeding, worsens. The gingival papillae and marginal gums may begin to grow. This type of gingivitis is called hypertrophic. It is especially pronounced in the area of the front teeth and in places where there are overhanging edges of crowns and fillings that injure the gums. Hypertrophic gingivitis comes in two forms:

edematous – the gingival papillae enlarge, become blue in color, become soft to the touch, have polypous growths or a loose structure;
fibrous – the gingival papillae enlarge and at the same time become dense.

Analogs

An analogue of Metrogil dent is Metrodent dental gel. It has an almost identical composition, is prescribed in the same clinical cases and has the same contraindications. Its use is justified only by the fact that it is cheaper than Metrogil dent. It is not prescribed in the first trimester, and in the future - taking into account the benefits for the mother and the risk for the child.
Dentamet gel is used with the same features. It cannot be used in the first trimester. In the second and third trimester, the drug is prescribed with caution.
Transparent gel Elugel relieves inflammation, eliminates bleeding gums and alleviates the condition of the expectant mother. Doctors allow its use at any stage of gestation. A special feature of the drug is its possible use in the event that a toothbrush and hygienic toothpaste are temporarily prohibited for some reason.

The drug to replace Metrogil dent is selected only by the dentist, taking into account the diagnosis, characteristics of women’s health, gestational age, severity of the disease and the presence of open wounds.