Which is better for a fracture, Nise or Ketorol?

Nise and Ketorol: which is better

A drug from the group of non-acid NSAIDs.
The active component is nimesulide, a substance belonging to the class of sulfonamides. The mechanism of action is to suppress the activity of cyclooxygenase-2, an isoenzyme involved in the synthesis of prostaglandins at the site of inflammation. This reduces the formation of inflammatory mediators, pain and fever.

What makes nimesulide unique, unlike other NSAIDs, is its selectivity of action. The substance has virtually no effect on the activity of COX-1 - isoenzymes that ensure the normal condition of the mucous membranes of the gastrointestinal tract. As a result, the drug with nimesulide causes less harm to the digestive system than analgesics that do not have selective properties.

In addition, it does not have a negative effect on cartilage tissue, so it can be prescribed for a long course if necessary.

Nise is produced in the form of tablets and suspension for oral administration, and gel for external application. Prescribed for:

Arthritis (rheumatoid, psoriatic)
Exacerbation of gout in the form of articular syndrome
Ankylosing spondylitis
Osteochondrosis with concomitant radicular syndrome
Osteoarthrosis
Myalgia
Inflammatory processes in ligaments, tendons (including post-traumatic inflammation in soft tissues)
Pain of various origins.

Pills. It is recommended to take 1 piece for adults and adolescents from 12 years of age. 2 rubles/day The maximum daily amount is 200 mg. For patients with renal pathologies, the dosage should be halved. The tablets should be taken before meals, but if discomfort appears after taking them, it is better to take them at the end of the meal or immediately after it ends.
Suspension. Adults – 100 mg 2 times a day. The drug can be prescribed to children in a dosage calculated according to age and body weight: 1.5 mg/kg BW. Frequency of administration – 2-3 times per day. The maximum daily amount of drugs should not exceed 5 mg/kg.
Gel. The drug is applied to the previously washed and dried surface of the painful area 3-4 times a day. No rubbing required. Can be used for no longer than 10 days without medical advice.

How to use

Compressed tablets for toothache are prescribed to people whose weight exceeds 40 kg. These patients can take one pill (after meals) twice a day with plenty of water. In severe cases, when the pain returns more often than three hours between attacks, you can reduce the intervals between doses of the medicine. However, it should be remembered that the maximum daily dose should not exceed 400 mg (or 4 pills).

If after taking 2-3 Nise tablets for toothache there is no improvement, then the problem is not its low effectiveness, but the nature of the disease itself. In this case, abuse of the drug can lead to problems with the gastrointestinal tract, kidneys and liver, without having a therapeutic effect.

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Dispersible tablets are dissolved in 5 ml of water (one teaspoon), then the solution is drunk. The suspension is prescribed to children under 12 years of age. The doctor calculates the dose of the drug “Nise” taking into account the child’s weight: per 1 kg of body weight – 3-5 mg of the active substance. The total dose is divided in half into morning and evening doses.

Dentists advise taking the suspension before meals, but if the child complains of discomfort, then it is better to drink the medicine after meals. An effective course of symptomatic treatment with Nise does not exceed 10 days; an increase in this period should take place under strict monitoring of kidney function by a doctor.

Ketorol

The drug is also intended for the symptomatic elimination of pain, fever and inflammatory processes, but its effect is ensured by another active component - ketorolac.
The substance is a derivative of acetic acid. Through its effect on both types of COX, it inhibits the metabolism of arachidonic acid and the associated synthesis of prostaglandins.

When used externally, it reduces or completely eliminates pain at the treatment site. As a result, the condition of the joints in motion and at rest improves, morning stiffness and swelling disappear, and motor activity increases.

The drug is recommended for use in moderate and severe pain syndromes of various origins. Indications for use:

Pain after injuries, operations
Headache, toothache
Alleviating the condition of cancer patients
Myalgia
Arthralgia
Exacerbation of radiculitis
Neuralgia
Pain due to dislocations, bruises, sprains.

The drug is produced in the form of tablets for oral administration, injection solution, and gel for external treatment.

Tablets: single dosage – 10 mg, frequency of administration – maximum 4 r. in a day.
Injections: with IM - a single dosage of 10-30 mg, with IV - in a dose calculated according to the patient’s age, weight and kidney condition. The interval between injections is 4 hours.
Gel: The drug is applied to the affected area with a 4-hour break.

What's better

Both drugs are non-narcotic analgesics that have similar effects. Therefore, it is difficult to determine the advantage of Ketorol or Nise, and even more so, which is better for the patient, without knowing his diagnosis and characteristics of the body.

General contraindications

Both drugs should not be prescribed for similar risk factors. In addition to the individual reaction, they are prohibited when:

Severe pathologies of the liver, kidneys
Exacerbation of gastrointestinal diseases
Bleeding
Aspirin triad
Decompensated heart failure
Coagulation system disorder
Hyperkalemia
The period after ACS
Pregnancy, GW
For the gel: dermatoses, weeping dermatoses, infections at the site of intended treatment.

Which is stronger

Ketorol is considered one of the most powerful non-narcotic painkillers. Its active substance, ketorolac, is so effective in relieving severe pain that it is often compared to morphine. Due to this feature, Ketorol can be prescribed even to patients with cancer.

Nise is somewhat inferior to its competitor in terms of analgesic effect, but is more effective in eliminating inflammation and reducing fever.

Ketorol and Nise: what is the difference

For severe pain it is better to use Ketorol, for inflammation and high fever - Nise.
The analgesic effect occurs more quickly after taking Ketorol, Nise acts more slowly: for up to an hour and a half.
Nise causes less damage to the gastrointestinal tract.
Nise can be given to children from 3 years of age (dispersible tablets), Ketorol - only from 16 years of age.
Nise is recommended for people who have problems with the gastrointestinal tract, since nimesulide acts more sparingly than ketorolac contained in Ketorol.

Both drugs are intended for symptomatic therapy, and the mechanism of action is broadly similar. But since Ketorol and Nise contain different substances and differ in the selectivity of their effect on COX, they have slightly different effects on the body. Therefore, the right to choose drugs for therapy should remain with the attending physician.

Source of the article: https://lekhar.ru/lekarstva/obezbolivajushhie-preparaty/najz-ili-ketorol/

Names of effective painkillers

What pills will help with headaches and toothaches? Each remedy for toothache, an analgesic or another painkiller, affects a person in its own way - it all depends on the individual characteristics of the body, on the nature and cause of the toothache. There is a list of those drugs that are most effective for inflammation and pain in the teeth: Ketanov, Validol, Nimesil, Nise, Nurofen, Tempalgin (green tablets) and other products.

Validol

If you suddenly have a toothache at home, and there are no special products in the first aid kit, then you are allowed to use Validol, which is intended for the heart. To do this, you need to take 1 tablet of the medicine, mash it and add a little water until a medium-thick paste forms. Using the resulting mixture, carefully apply the gum around the diseased tooth. After some time, the pain will go away.

Nise is a drug with a strong and rapid effect. After taking the pill, you need to wait a few minutes and the pain will go away. It is for this reason that the drug is allowed to be taken only for severe and unbearable pain. The Naiza tablet is effective for at least 6 hours. The drug should not be taken by pregnant or lactating women or children under 2 years of age.

Ketanov

If you are overcome by severe or moderate tooth pain, which for some reason does not go away, then you can take one Ketanov tablet. The drug has a large list of contraindications. It should not be taken by pregnant women, during lactation, or children under 16 years of age. The drug is not recommended for patients suffering from bronchial asthma, liver and kidney diseases. Ketanov can cause migraines and diarrhea as side effects.

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Nurofen

With the help of a drug such as Nurofen, you can get rid of not only severe toothache, but also the accompanying symptoms. Nurofen is available for adults and children in appropriate forms and dosages. For children, starting from infant age, suppositories and syrups with fruit flavor are produced.

The drug Nurofen is quite often prescribed after tooth extraction. It is often used in the postoperative period.

Nimesil

To relieve toothache of any nature, Nimesil is often used, which is available in the form of tablets and powder. The drug is prescribed for a variety of symptoms: aching gums, pain due to neuralgia of the jaw, etc.

Nimesil has a minimum of contraindications and is highly effective against tooth pain. It begins to act within half an hour after administration. Please note that each dose of the drug should occur no more often than 12 hours after the previous one.

Bellasthesin

Bellastesin helps very well with toothache of varying intensity. It is available in tablet form and has an attractive price. Bellasthesin can either be taken or placed on the tooth. It acts quickly and relieves pain for 6-8 hours. Bellasthesin has a wider application than it might seem: the drug, in addition to acute toothache, will perfectly relieve pain associated with the gastrointestinal tract.

Nimid

Nimid has the same active ingredient as the previous drug called Nemisil - nemisulide. This drug is also good for toothache. Nimid is available not only in tablets, but also in powder form, which is much more convenient to use. In addition, Nimid powder, which is diluted with water, acts much faster than a tablet.

Dexalgin

Dexalgin is an anti-inflammatory non-steroidal drug. You can buy it at the pharmacy both in tablet form and in the form of an injection solution. Having taken a Dexalgin tablet, you can expect its effect within minutes. As for the effect of the drug, it is quite long-lasting.

A medicine called Dexalgin should not be taken for a long time. You should not take more than 3 tablets per day. Among the contraindications that the drug has are bronchial asthma, peptic ulcers of the stomach and duodenum.

Valocordin

Folk remedies that help with toothache include Valocordin. To get rid of tooth pain, you need to put a few drops of Valocordin on a cotton swab and apply it to the area that is bothering you. After some time, the pain will begin to subside, which is facilitated by the substances contained in Valocordin: valerian, phenobarbital and peppermint essential oil. The medicine can also be used for headaches in the same way.

Nise and Ketorol: comparison and which product is better to take

Pain is a condition that every person encounters at least once in their life. According to statistics from popular online stores, painkillers are consistently among the top ten most purchased products.

When choosing analgesics, the average buyer's eyes widen: the choice is very large. After reading this article, you will understand which medicine to give preference to for pain relief: “Nise” or “Ketorol”.

Both drugs belong to the same group: non-steroidal anti-inflammatory drugs (NSAIDs). To understand what choice to make in a particular case, you need to understand a little about how NSAIDs work.

What will help with toothache

To relieve toothache, you can use tablets of two groups - analgesics (Ibufen, Nimesil) and non-steroidal anti-inflammatory drugs (Ketonal, Komistad). You can take them in case of severe toothache to provide first aid, and then consult a dentist for treatment. It is better not to take tablets for toothache immediately before visiting a doctor, or if there is acute inflammation in the oral cavity, which can hide symptoms and complicate diagnosis.

Let's look at the main groups of analgesic and non-steroidal anti-inflammatory drugs (NSAIDs) that can be taken for severe toothache in children and adults.

Among the anti-inflammatory drugs, it is worth highlighting Ketonal, Nurofen, Voltaren, Nise, Ketanov, Xefocam. Complex drugs Sedalgin, Pentalgin, Tempalgin also help with pain.

"Ketorol"

The active ingredient of Ketorol is ketorolac. The mechanism of action of ketorolac is based on the suppression of COX types 1 and 2. That is, “Ketorol” is a non-selective pain reliever.

Ketorolac has the following effects:

Anti-inflammatory effect.
Pronounced pain reliever.
Moderate antipyretic.

The analgesic effect is comparable to that of morphine. "Ketorol" acts quickly: pain decreases within 10-78 minutes after administration.

Indications

The drug is prescribed to relieve severe pain with:

Injuries.
Dental diseases.
In the postoperative period.
For pain in the back, joints, muscles.

Contraindications

"Ketorol" has the same contraindications as "Nise". Additionally, due to its non-selective effect on COX, the drug cannot be used for:

Blood clotting disorders.
Heart failure.
In the period after surgery to install a coronary bypass.
Not used to prepare for anesthesia before surgery due to the increased risk of bleeding.
Age up to 16 years.

Nise or Ketonal?

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to suppress inflammatory processes in the body. They effectively reduce the intensity of inflammation, which significantly reduces pain in the joints in various pathologies of the musculoskeletal system or, for example, back pain in diseases of the spine.

There are contraindications and side effects, use after consulting your doctor

What's stronger?

Ketonal has a more intense

analgesic (pain-relieving) effect, and in terms of the strength of the anti-inflammatory effect, these drugs are approximately equal.

But it is important to remember that ketoprofen indiscriminately inhibits both COX-2 and cyclooxygenase-1 (an enzyme responsible for protecting the gastrointestinal mucosa from aggressive factors), and therefore much more often causes adverse reactions associated with damage to the stomach or intestines.

While nimesulide almost does not suppress COX-1, which makes it safer from the gastroenterological side, especially for people who already have problems with the gastrointestinal tract.

Both drugs are prohibited for use during pregnancy; Ket can be taken only in exceptional cases.

(except for the third trimester), if its use will bring more benefits to the health of the mother than it will cause possible harm to the condition of the fetus.

A significant difference between Nise is the likelihood of its negative impact on women’s fertility (the ability to conceive), therefore, when planning pregnancy for the near future, women should not use it for treatment.

Which of the external forms of drugs is better?

Both drugs are locally prescribed for the symptomatic treatment of pain accompanied by inflammatory processes of various etiologies. These drugs are successfully used for arthritis, osteochondrosis, myalgia, neuralgia, radiculitis, sprains, dislocations and bruises.

Comparing local forms, it should be noted that 2.5% Ketonal gel has the most pronounced therapeutic effect, so its use is justified in case of pronounced pain syndrome in the acute phase.

Gel 2.5%

Nise gel is best used for moderate or mild chronic pain. Moreover, both drugs are prescribed for joint or muscle pain when its source is close to the surface. If the source of pain is located deep enough (for example, in the hip joints) or the person is obese, then local forms of medications may not have a pronounced effect.

You also need to remember that ointments and gels, when applied to a large surface area (five palms or more), have the same contraindications and side effects as dosage forms intended for oral administration.

Comparing the cost of Ketonal ointment or Nise gel, we can say that the prices in such identical dosage forms are approximately comparable to each other, although Ketonal is slightly more expensive than its opponent.

Show payment for the drug

Source: https://www.kliwi.ru/2016/09/naiz-ili-ketonal.html

Differences between "Nise" and "Ketorola"

If you study the instructions for these drugs, it becomes clear that there are differences:

“Nise” has more pronounced anti-inflammatory and antipyretic effects. Ketorol copes better with pain.
The effect of Ketorol begins within 10 minutes after administration. The effect of “Nise” will have to wait longer: from 1.5 hours.
“Nise”, due to its selective action, causes fewer side effects than “Ketorol”.
"Nise" can be used by children from 3 years of age (in the form of soluble tablets). "Ketorol" has stricter age restrictions - from 16 years.
"Nise", unlike "Ketorol", does not increase the risk of bleeding. Therefore, it is safer to use in the postoperative period, for example, after tooth extraction.

What is the difference?

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What to choose?

Since both “Nise” and “Ketorol” are prescription drugs, the decision on what to choose is made by the attending physician. The following are just sample recommendations:

"Ketorol" is better suited for adults, healthy people with severe pain of any origin. Healthy means there should be no diseases of the stomach, intestines, or hematopoietic system.
"Ketorol" can be used in cases where pain needs to be relieved quickly.
"Nise" is suitable for older people who have chronic diseases.
For toothache, the choice of drug depends on the situation. “Nise” is suitable when there is an increased temperature, for example during flux. “Ketorol” will more effectively relieve severe pain due to pulpitis, deep caries, etc.

Source of the article: https://vchemraznica.ru/najz-i-ketorol-sravnenie-i-kakoe-sredstvo-luchshe-vzyat/

Is it possible to take these drugs together?

The main disadvantage of non-steroidal anti-inflammatory drugs is that they have many side effects and, as a consequence, a large list of contraindications. They are strictly not recommended to be used together. This will not increase the therapeutic effect, but the side effects will be the opposite. NSAIDs affect platelet aggregation (reduce blood clotting) and negatively affect the mucous membranes of the gastrointestinal tract, primarily for non-selective ones (which include Ketorol). If you take them together (especially for those who have a history of chronic gastritis, stomach and/or intestinal ulcers), it is very easy to get complications in the form of internal bleeding.